Journal
MOLECULES
Volume 6, Issue 10, Pages 815-824Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL
DOI: 10.3390/61000815
Keywords
substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1,2,4-triazoles; cyclization; inhibition zone
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A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, H-1-NMR, C-13-NMR and UV spectral data together with elemental analysis.
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