Journal
IMMUNITY
Volume 15, Issue 4, Pages 671-682Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(01)00217-5
Keywords
-
Categories
Funding
- NIAID NIH HHS [R37-AI36059, R01-AI36554, R01-AI43695] Funding Source: Medline
- NIDCR NIH HHS [T32-DEO7296] Funding Source: Medline
Ask authors/readers for more resources
Although HIV-1 gene expression is detected in naive, resting T cells in vivo, such cells are resistant to productive infection in vitro. However, we found that the endogenous. microenvironment of human lymphoid tissues supports de novo infection and depletion of this population. Cell cycle analysis and DNA labeling experiments established that these cells were definitively quiescent and thus infected de novo. Quantitation of the burst size within naive cells further demonstrated that these cells were productively infected and contributed to the local viral burden. These findings demonstrate that lymphoid tissues support active HIV-1 replication in resting, naive T cells. Moreover, these cells are not solely reservoirs of latent virus but are permissive hosts for viral replication that likely targets them for elimination.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available