Journal
DEVELOPMENTAL BIOLOGY
Volume 238, Issue 1, Pages 202-212Publisher
ACADEMIC PRESS INC
DOI: 10.1006/dbio.2001.0405
Keywords
N-cadherin; pancreas; apoptosis; mesenchyme; endoderm
Categories
Funding
- NHLBI NIH HHS [HL57554] Funding Source: Medline
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Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme. (C) 2001 Academic Press.
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