Journal
NATURE REVIEWS CANCER
Volume 1, Issue 1, Pages 22-33Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35094000
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Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?.
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