Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 34, Issue 10, Pages 836-843Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar000118k
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Researchers' increasing awareness of the essential role played by RNA in many biological processes and in the progression of disease makes the discovery of new RNA targets an emerging field in drug discovery. Since most existing pharmacologically active compounds bind proteins, RNA provides nearly untapped opportunities for pharmacological development. The elucidation of the structure of the ribosome and other cellular and viral RNA motifs creates the opportunity for discovering new drug-like compounds that inhibit RNA function. However, further advances in understanding the chemistry and structure of RNA recognition are needed before these promises are fulfilled.
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