Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 5, Pages 505-512Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00225-2
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NFATc proteins transduce Ca2+ signals to the nucleus and then pair with other proteins on DNA to generate NFAT complexes that activate transcription in response to both electrical and tyrosine kinase signaling. The four NFATc genes arose at the origin of vertebrates, implying that they have evolved for the development of vertebrate-specific functions, such as a complex nervous system, a recombinational immune system, and a vascular system with a complex heart. These speculations are borne out by studies of mice with null mutations in the different family members.
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