Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 27, Issue 5, Pages 473-482Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2001-17958
Keywords
heparin; NMR spectra; sulfation patterns; antithrombin binding sequence
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The sulfation patterns of pig and bovine mucosal commercial heparin preparations can be characterized and distinguished from each other easily by analysis of their monodimensional proton and carbon nuclear magnetic resonance (H-1 and C-13-NMR) spectra. NMR spectroscopy can detect and quantify signals associated with major sequences as well as with minor residues such as the typical ones associated with the antithrombin (AT) binding sequence and the linkage region. Contaminants arising from industrial preparation processes are also detectable.
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