Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 108, Issue 8, Pages 1205-1213Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI13103
Keywords
-
Categories
Funding
- NIDDK NIH HHS [DK-3320] Funding Source: Medline
Ask authors/readers for more resources
Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of uncoupling protein-1 and -2. In parallel, these mice develop an insulin-secretion defect resulting in a progressive glucose intolerance, without insulin resistance. This model provides direct evidence for not only a role for the insulin receptors in brown fat adipogenesis, the data also suggest a novel role of brown adipose tissue in the regulation of insulin secretion and glucose homeostasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available