Journal
IMMUNITY
Volume 15, Issue 4, Pages 545-555Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(01)00219-9
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- PHS HHS [52094] Funding Source: Medline
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PU.1(+/-)Spi-B-/- mice exhibit reduced numbers of immature and mature B lymphocytes, which exhibit severe defects in response to BCR-mediated stimulation and poor survival. We found that expression of c-rel, a member of the Rel/NF-kappaB family, is dramatically reduced in PU.1(+/-)Spi-B-/- splenic B cells. Analysis of the murine c-rel promoter identified three PU.1/Spi-B binding sites critical for c-rel promoter activity. Furthermore, reintroduction of Rel protein restored wild-type B cell numbers to mice reconstituted with PU.1(+/-)Spi-B-/- bone marrow. These findings are the first to demonstrate that a member of the Rel/NF-kappaB family is directly regulated by Ets proteins and dissect the molecular basis for the function of two Ets factors, PU.1 and Spi-B, in promoting B lymphocyte survival.
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