Journal
ARCHIVES OF MICROBIOLOGY
Volume 176, Issue 4, Pages 285-293Publisher
SPRINGER-VERLAG
DOI: 10.1007/s002030100324
Keywords
cyclosporin A; cyclosporin synthetase; Tolypocladium inflatum; compartmentation; immunoelectron microscopy
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The electron microscopic image of native cyclosporin synthetase molecules showed large globular complexes of 25 nm in diameter, built up by smaller interconnected units. Compartmentation of cyclosporin synthetase and the functionally interconnected D-alanine racemase was revealed after sucrose density gradient centrifugation of subcellular fractions and immunoelectron microscopy. A considerable proportion of cyclosporin synthetase and D-alanine racemase was detected at the vacuolar membrane. The product cyclosporin was localized in the fungal vacuole.
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