Journal
APOPTOSIS
Volume 6, Issue 5, Pages 353-358Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1011386002874
Keywords
gastric cancer cells; apoptosis-resistance; sorbitol-induced apoptosis; PKC down-regulation; overcoming apoptosis-resistance
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Although apoptosis-dependent involution of malignant tumors is associated with a number of non-surgical treatments including chemotherapy, most solid tumors, including gastric cancers, respond poorly to these therapies. In the hope of overcoming the resistance mechanism against non-surgical therapies, we studied the apoptosis-resistance mechanism in cells of gastric cancers as a model system. During the course of our study on apoptotic machinery in human gastric cancer cell lines, we previously found a rapid and efficient induction of apoptosis by sorbitol. In the present study, we demonstrated that the down-regulation of PKC activity in response to sorbitol is a major factor in the induction of apoptotic cell death in gastric cancer cells.
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