Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 10, Pages 1278-1281Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np010211x
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Funding
- NIAID NIH HHS [AI 33066] Funding Source: Medline
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A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC50 <0.1 mug/mL, TI > 186) and was modified to develop more potent anti-AIDS agents.
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