Journal
JOURNAL OF AUTOIMMUNITY
Volume 59, Issue -, Pages 85-90Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2015.03.002
Keywords
Epidemiological study; Periodontal disease; ACPA; RF; Association study; Rheumatoid arthritis
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology in Japan
- Japan Society for the Promotion of Science
- Takeda Science Foundation, Japan
- Grants-in-Aid for Scientific Research [25463081, 15K08646] Funding Source: KAKEN
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Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT. CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p <= 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production. (C) 2015 Elsevier Ltd. All rights reserved.
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