Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 179, Issue -, Pages 351-355Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.179.4.351
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Background Evidence exists for an association between aggression and schizophrenia. Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia. Aims To replicate these findings in a larger sample using the Overt Aggression Scale (OAS). Method A sample of 180 people with DSM-IV schizophrenia were rated for aggression using the OAS. Kruskal-Wallis and contingency table analyses were applied to the OAS results. Results The high-activity homozygotes showed significantly higher scores of aggression, whereas the heterozygotes showed significantly lower scores. The odds ratio for aggression for the high-activity homozygotes was 2.07 (95% CI=1.03-4.15), whereas that for the heterozygotes was 0.54 (95% CI=0.30-1.00). Conclusions The high-activity COMT homozygote confers a higher risk of recorded aggression in schizophrenia. Heterozygotes had a significantly lower risk, which may represent an example of heterosis/heterozygote advantage.
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