Journal
JOURNAL OF AUTOIMMUNITY
Volume 63, Issue -, Pages 47-58Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2015.07.002
Keywords
Type I interferon; Type II interferon; Sjogren's syndrome; Lymphomagenesis; B cell activating factor
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Funding
- Arthritis Foundation
- New York Chapter
- Hellenic Rheumatology Association
- Stavros Niarchos Foundation Research Grant
- NIH [R01AI059893]
- Lupus Research Institute
- Alliance for Lupus Research
- Mary Kirkland Center for Lupus Research
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Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren's syndrome (SS). We aimed to explore the contribution of type I and II IFN signatures in the generation of distinct SS clinical phenotypes including lymphoma development. Peripheral blood (PB) from SS patients (n = 31), SS patients complicated by lymphoma (n = 13) and healthy controls (HC, n = 30) were subjected to real-time PCR for 3 interferon inducible genes (IFIGs) preferentially induced by type I IFN, 2 IFIGs preferentially induced by IFN gamma as well as for IFN alpha and IFN gamma genes. The same analysis was performed in minor salivary gland tissues (MSG) derived from 31 SS patients, 10 SS-lymphoma patients and 17 sicca controls (SC). In PB and MSG tissues, overexpression of both type I and type II IFIGs was observed in SS patients versus HC and SC, respectively, with a predominance of type I IFN signature in PB and a type II IFN signature in MSG tissues. In SS-lymphoma MSG tissues, lower IFN alpha, but higher IFN gamma and type II IFIG transcripts compared to both SS and SC were observed. In receiver operating characteristic curve analysis, IFN gamma/IFN alpha mRNA ratio in MSG tissues showed the best discrimination for lymphoma development. Discrete expression patterns of type I and II IFN signatures might be related to distinct SS clinical phenotypes. Additionally, IFN gamma/IFN alpha mRNA ratio in diagnostic salivary gland biopsies is proposed as a novel histopathological biomarker for the prediction of in situ lymphoma development in the setting of SS. (C) 2015 Elsevier Ltd. All rights reserved.
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