Journal
NATURE NEUROSCIENCE
Volume 4, Issue 10, Pages 1006-1013Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn717
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Funding
- NIDCD NIH HHS [DC02961, R01 DC002961] Funding Source: Medline
- NINDS NIH HHS [NS37159, R29 NS037159] Funding Source: Medline
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The dynamics of postsynaptic density (PSD) formation and remodeling were investigated in live developing hippocampal tissue slices. Time lapse imaging of transfected neurons expressing GFP-tagged PSD95, a prominent PSD protein, revealed that up to 40% of PSDs in developing dendrites are structurally dynamic; they rapidly (<15 min) appear or disappear, but also grow, shrink and move within shafts and spines. New spines containing Ms were formed by conversion of dynamic filopodia-like spine precursors in which PSDs appeared de novo, or by direct extension of spines or spine precursors carrying preformed PSDs from the shaft. Ms are therefore highly dynamic structures that can undergo rapid structural alteration within dendrite shafts, spines and spine precursors, permitting rapid formation and remodeling of synaptic connections in developing CNS tissues.
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