Journal
BEHAVIOR GENETICS
Volume 38, Issue 3, Pages 277-291Publisher
SPRINGER
DOI: 10.1007/s10519-008-9203-6
Keywords
fear conditioning; albino; tyrosinase (tyr); selection; QTL; gene expression
Funding
- NIGMS NIH HHS [T32GM07088, T32 GM007839, T32 GM007088, T32GM07839] Funding Source: Medline
- NIMH NIH HHS [K01 MH070933, MH79103, MH70933, R01 MH079103] Funding Source: Medline
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We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning. Within two generations of selection all low selected mice were homozygous for the recessive tyr(c) allele and showed the corresponding albino coat color. Freezing differed in the high and low selected lines across a range of parameters. We identified several QTLs for the selection response, including a highly significant QTL at the tyr locus (p < 9.6(-10)). To determine whether the tyr(c) allele was directly responsible for the response to selection, we examined B6 mice that have a mutant tyr allele (tyr(c-2j-)) and an AJ congenic strain that has the wild-type B6 allele for tyr. These studies showed that the tyr allele had a small influence on fear learning. We used Affymetrix microarrays to identify many differentially expressed genes in the amygdala and hippocampus of the selected lines. We conclude that tyr is one of many alleles that influence fear conditioning.
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