Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 52, Issue 1-2, Pages 5-13Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0165-0378(01)00118-8
Keywords
pregnancy; fetal allograft; maternal immunity; indoleamine 2,3-dioxygenase
Categories
Funding
- NHLBI NIH HHS [HL 60137] Funding Source: Medline
- NIAID NIH HHS [AI 44219] Funding Source: Medline
Ask authors/readers for more resources
The murine conceptus is protected from maternal immunity by cells expressing indoleamine dioxygenase (IDO), which catabolizes tryptophan. Induction of lethal maternal anti-fetal immunity requires effective pharmacologic inhibition of IDO enzyme activity and the presence of maternal T cells, but not B cells and also depends on the degree of maternal-fetal tissue incompatibility. Based on these findings, we propose a model to explain the role of IDO in suppressing maternal immunity and the mechanism of fetal allograft rejection, when IDO activity is inhibited during gestation. This model incorporates observations that fetal allograft rejection is T cell dependent, antibody-independent and is accompanied by a novel type of inflammation involving extensive complement deposition at the maternal-fetal interface, when IDO activity is blocked during murine pregnancy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available