Journal
CHEMICAL SENSES
Volume 26, Issue 8, Pages 965-969Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/26.8.965
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Studies in the last two decades have shown that amiloride-sensitive Na+ channels play a role in NaCl transduction in rat taste receptors. However, this role is not readily generalized for salt taste transduction in vertebrates, because functional expression of these channels varies across species and also in development in a species. Glossopharyngeal nerve responses to sodium and potassium salts were recorded in larval and metamorphosed salamanders and compared before and after the oral floor was exposed to amiloride, a blocker of Na+ channels known to be responsible for epithelial ion transport. Pre-exposure to amiloride (100 muM) did not affect salt taste responses in both axolotis (Ambystoma mexicanum) and larval Ezo salamanders (Hynobius retardatus). In contrast, in metamorphosed Ezo salamanders the nerve responses to NaCl were significantly reduced by amiloride. In amphibians amiloride-sensitive components in salt taste transduction seem to develop during metamorphosis.
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