Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 17, Issue 2, Pages 101-118Publisher
HUMANA PRESS INC
DOI: 10.1385/JMN:17:2:101
Keywords
aging; mild cognitive impairment; Alzheimer's disease; amyloid plaques
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Funding
- NIA NIH HHS [AG03991, AG05681] Funding Source: Medline
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The results of studies from the Washington University Alzheimer Disease (AD) Research Center and those from other centers and investigators regarding the neuropathologic correlates of normal aging and early-stage AD are reviewed. We conclude that widespread amyloid plaques in the neocortex best distinguishes very early stage AD, including MCI stage, and preclinical stages, from healthy brain aging. Other AD lesions, including increased formation of neurofibrillary tangles and neuronal degeneration appear to result from the amyloid-initiated pathologic process, although they may have a more immediate effect on expression and severity of dementia. These data provide strong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life.
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