Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 11, Issue 5, Pages 629-634Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00258-X
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Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation.
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