Journal
GENES & DEVELOPMENT
Volume 15, Issue 19, Pages 2509-2514Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.208901
Keywords
polycomb silencing; ESC/PHO; PcG complex
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Two distinct types of Polycomb complexes have been identified in flies and in vertebrates, one containing ESC and one containing PC. Using LexA fusions, we show that PC and ESC can establish silencing of a reporter gene but that each requires the presence of the other. In early embryonic extracts, we find PC transiently associated with ESC in a complex that includes EZ, PHO, PH, GAGA, and RPD3 but not PSC. In older embryos, PC is found in a complex including PH, PSC, GAGA, and RPD3, whereas ESC is in a separate complex including EZ, PHO, and RPD3.
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