Journal
INFECTION AND IMMUNITY
Volume 69, Issue 10, Pages 6515-6519Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.10.6515-6519.2001
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Funding
- NIAID NIH HHS [R01 AI038281, AI38281-05] Funding Source: Medline
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Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage than did infection with isogenic CNF1-negative mutants. These striking differences occurred despite the finding that bacterial counts for the strain pairs were indistinguishable. We conclude that CNF1 contributes to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the first demonstration of a role for any uropathogenic E. coli virulence factor in acute prostatitis.
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