Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 20, Pages 9966-9976Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.20.9966-9976.2001
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Funding
- NIAID NIH HHS [R01 AI033852, AI33852, AI30363, R21 AI030363, K08 AI 01638, R01 AI030363, R56 AI030363] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07328] Funding Source: Medline
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The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is an important determinant of dissemination during primary infection. Reduced peak levels of viremia at day 5 were followed by reduced levels of virus in salivary glands starting at day 7 when mck insertion (RM461) and point (RM4511) mutants were compared to mck-expressing viruses. A dramatic MCK-2-enhanced inflammation occurred at the inoculation site over the first few days of infection, preceding viremia. The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host.
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