Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 9, Issue 10, Pages 2557-2563Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0968-0896(01)00030-X
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Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments have demonstrated that these aptamers recognize a disaccharide analogue of moenomycin. The results offer the opportunity of setting up a selective and sensitive assay for identifying moenomycin biosynthetic precursors. (C) 2001 Elsevier Science Ltd. All rights reserved.
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