Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 49, Issue 10, Pages 1362-1365Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.49.1362
Keywords
pyrrolidine alkaloid; alpha-glucosidase inhibitor; Lobelia chinensis; Campanulaceae; radicamine A; radicamine B
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Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of alpha -glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.
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