Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 10, Pages 731-737Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35096061
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The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
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