Journal
BRITISH JOURNAL OF SPORTS MEDICINE
Volume 35, Issue 5, Pages 342-343Publisher
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/bjsm.35.5.342
Keywords
depression; exercise; phenylacetic acid; phenylethylamine
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Objectives-To determine in this pilot study whether aerobic exercise affects phenylacetic acid concentration in the urine. Methods-Twenty healthy men provided 24 hour urine samples on two consecutive days for the determination of phenylacetic acid levels. Before and during day 1, subjects refrained from physical activity; on day 2 subjects ran on a treadmill at 70% of their maximal heart rate reserve (MHRR) for 30 minutes. Results-The 24 hour mean urinary concentration of phenylacetic acid was increased by 77% after exercise. Conclusion-As phenylacetic acid concentration in urine reflects phenylethylamine level, which is known to have antidepressant effects, phenylethylamine may be linked to the therapeutic effects of physical exercise on depression.
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