Journal
DEVELOPMENTAL CELL
Volume 1, Issue 4, Pages 453-465Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(01)00060-0
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Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge.
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