Journal
INFECTION AND IMMUNITY
Volume 69, Issue 10, Pages 6554-6557Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.10.6554-6557.2001
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The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.
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