Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 13, Issue 5, Pages 555-561Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(00)00258-2
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Funding
- NIAID NIH HHS [R01 AI 45051] Funding Source: Medline
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Since their discovery as cells bearing both TCRs and NK cell receptors, NKT cells have been intensively studied as a possible bridge between innate and adaptive immunity. Although their involvement in a wide variety of immune responses and in disease states have been well documented, molecular details of this functionality have been lacking. Recently, transcriptional profiling using microarrays has been applied to these cells, pinpointing gene-expression differences between this regulatory T cell subset and conventional T cells, and providing a framework for subset-specific therapeutic intervention in clinical settings.
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