Journal
BASIC RESEARCH IN CARDIOLOGY
Volume 107, Issue 3, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-012-0260-x
Keywords
Ischemia; Reperfusion; Cardioprotection; Exercise; Remote ischemic preconditioning; Humoral factor
Categories
Funding
- Foundation Leducq [CVD 06]
- Danish Agency for Science, Technology and Innovation [11-108354, 11-115818]
- Canadian Institutes of Health Research
- Lundbeck Foundation
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Exercise protects against myocardial ischemia-reperfusion (I-R) injury but the mechanism remains unclear. Protection can be transferred from a remotely preconditioned human donor to an isolated perfused rabbit heart using a dialysate of plasma. We hypothesized that physical exercise preconditioning also confers cardioprotection through a humorally mediated effector dependent on opioid receptor activation. Thirteen male volunteers performed vigorous exercise (four 2-minute bouts of high-intensity exercise) and 1 week later they underwent remote ischemic preconditioning (four cycles of 5 min upper limb ischemia and reperfusion). Dialysates were prepared from blood collected before (control) and after the two interventions. Isolated rabbit hearts were perfused with the dialysates without and with co-administration of naloxone (opioid receptor antagonist) prior to 40 min regional ischemia and 2 h reperfusion. Exercise and remote ischemic preconditioning (rIPC) reduced infarct size from 60 +/- 5 to 35 +/- 5 % and from 57 +/- 7 to 27 +/- 3 % of the area at risk, respectively (p < 0.05 and < 0.01). Furthermore, post-ischemic left ventricular developed pressure was improved compared with controls (p = 0.08 for exercise and p = 0.04 for rIPC). Co-perfusion with naloxone abrogated the protective effects of exercise and remote ischemic preconditioned dialysates. In conclusion, high-intensity exercise preconditioning elicits cardioprotection through a humorally mediated dependent on opioid receptor activation, similar to rIPC.
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