Journal
BASIC RESEARCH IN CARDIOLOGY
Volume 106, Issue 5, Pages 735-747Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-011-0190-z
Keywords
NADPH oxidase; Cardiovascular; Redox signaling; Cardiac hypertrophy; Hypertension; Atherosclerosis
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Funding
- British Heart Foundation [RG/08/011/25922, CH/99001, RE/08/003]
- Leducq Foundation
- EU [LSHM-CT-2005-018833]
- British Cardiovascular Society
- National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- British Heart Foundation [RG/08/011/25922] Funding Source: researchfish
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NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.
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