Journal
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Volume 54, Issue 5, Pages 285-288Publisher
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/mp.54.5.285
Keywords
insulin-like growth factors; insulin-like growth factor binding proteins; tumour marker
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Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.
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