Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 11, Issue 5, Pages 568-578Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(00)00251-8
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Funding
- NEI NIH HHS [F32 EY007016, 1F32EY07016] Funding Source: Medline
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It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.
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