Journal
BASIC RESEARCH IN CARDIOLOGY
Volume 103, Issue 2, Pages 87-94Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-008-0707-2
Keywords
atherosclerosis; molecular imaging; fluorescence; MRI
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Funding
- NHLBI NIH HHS [U01 HL080731-03, K08 HL079984, U01 HL080731, R01-HL078641, R01 HL078641, R01 HL078641-03, U01-HL080731] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL078641, K08HL079984, U01HL080731] Funding Source: NIH RePORTER
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Our understanding of the intricate inflammation biology underlying atherosclerosis is rapidly progressing. Molecular imaging strategies, harnessing this body of knowledge, have been developed to visualize some key cellular and molecular events in plaque evolution and vulnerability. Here, we discuss recent advances in magnetic resonance and fluorescence imaging of key biomarkers including adhesion molecules, inflammatory cells, and enzyme activity. We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches.
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