Journal
BREAST CANCER RESEARCH
Volume 3, Issue 6, Pages 351-355Publisher
BMC
DOI: 10.1186/bcr321
Keywords
APC; breast cancer; beta-catenin; mouse mammary tumor virus; Wnt signaling
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Funding
- NCI NIH HHS [R01 CA047207] Funding Source: Medline
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Since the original identification of Wnt1 as a mammary oncogene in mouse mammary tumor virus infected mice, questions have been asked about its relevance to human breast cancer. Wnt1 is now known to be one of a large family of Wnt genes encoding structurally similar secreted signaling proteins, several of which are functionally redundant. The principal intracellular signaling pathway activated by these proteins has been elucidated in recent years. Components of this pathway include proto-oncogene products, such as beta-catenin, and tumor suppressor proteins such as APC. Although WNT1 itself has not been implicated in human breast neoplasms, it has been reported that other WNT genes are sometimes overexpressed in human breast cancer and there is growing evidence that downstream components of the Wnt signaling pathway are activated in a significant proportion of breast tumors.
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