4.8 Article

Synaptic plasticity: A molecular memory switch

Journal

CURRENT BIOLOGY
Volume 11, Issue 19, Pages R788-R791

Publisher

CELL PRESS
DOI: 10.1016/S0960-9822(01)00472-9

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Funding

  1. NIMH NIH HHS [T32 MH019929] Funding Source: Medline

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Recent work shows that two molecules with major roles in synaptic plasticity - CaMKII and the NMDA receptor bind to each other. This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural processes. (C) 2001 Elsevier Science Ltd. All rights reserved.

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