Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 227, Issue 1-2, Pages 5-26Publisher
ELSEVIER
DOI: 10.1016/S0378-5173(01)00781-5
Keywords
hard capsules; powder; filling properties; powder plug formation; instrumented machines; machine simulators; excipient properties; formulation optimisation
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The factors that influence the filling of powders into hard capsules are reviewed. Powder properties that affect machine performance and influence plug formation are highlighted. The use of instrumented machines and machine simulators in formulation development are described. The properties of excipients that are required for uniform filling are identified. The use of optimisation techniques to produce rational formulations is discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
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