Journal
NEUROREPORT
Volume 12, Issue 14, Pages 3033-3037Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200110080-00011
Keywords
670 nm; impulse blockade; LED; mitochondria; near-infrared; primary neuronal cultures; rat visual cortical neurons; tetrodotoxin
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Funding
- NEI NIH HHS [R01 EY05439] Funding Source: Medline
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Light close to and in the near-infrared range has documented benefits for promoting wound healing in human and animals. However, mechanisms of its action on cells are poorly understood. We hypothesized that light treatment with a light-emitting diode array at 670 nm (LED) is therapeutic in stimulating cellular events involving increases in cytochrome oxidase activity. LED was administered to cultured primary neurons whose voltage-dependent sodium channels were blocked by tetrodotoxin. The down-regulation of cytochrome oxidase activity by TTX was reverted to control levels by LED. LED alone also up-regulated enzyme activity. Thus, the results are consistent with our hypothesis that LED has a stimulating effect on cytochrome oxidase in neurons, even when they have been functionally silenced by TTX NeuroReport 12:3033-3037 (C) 2001 Lippincott Williams & Wilkins.
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