Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 21, Pages 3391-3401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm010878g
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Two compounds, obtained by random screening, and displaying micromolar activities on the At opiate receptor were used as starting points for optimization. In that work, the traditional concept of the activity of a compound (related to one or a few targets) was extended to the comprehensive pharmacological profile of that compound on more than 70 receptors, transporters, and channels relevant to a CNS-oriented project. Using the two complementary design strategies based on two similarity concepts described in the previous paper, we have obtained analogues with IC50 values ranging between 0.9 nM and a few micromolar on the mu receptor and displaying qualitatively different profiles. We discuss here, both on a case-by-case basis and from a statistical standpoint, the pharmacological profiles in light of the two similarity concepts.
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