Journal
VACCINE
Volume 20, Issue 1-2, Pages 98-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(01)00311-5
Keywords
HSV; US2; host immunity; US3
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We investigated the effects of US2 and US3 deficiencies of herpes simplex virus type 2 (HSV-2) on host immunity in a murine model of genital herpes infection. Viral clearance from the vaginal mucosa was more rapid in mice infected with a US3-deficient mutant L1BR1 as com,to pared with a wild-type 186 or YY2 (US2-deficient mutant) infection, although there was no significant difference among them in initial growth in the early stage of infection. Flow cytometric studies revealed that the number of vaginal mononuclear cells in L1BR1-infected mice was significantly greater than that in 186- or YY2-infected mice. Dendritic cells, macrophages and T cells were induced more rapidly and in greater numbers within the vaginas of LIBRI-infected mice. Moreover, the levels of IL-12 and IFN-gamma increased in LIBRI-infected mice over levels in 186-infected mice. These results indicate that a US3 deficiency alters the induction of the host immune response; therefore, the inactivation of US3 may be a promising strategy in the development of novel vaccines for genital herpes. (C) 2001 Elsevier Science Ltd. All rights reserved.
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