On the use of phosphine-free PdCl2(SEt2)2 complex as catalyst precursor for the Heck reaction

A simple and efficient experimental protocol has been developed for the catalytic arylation of alkenes by the air and water stable. and phosphine-free compound PdCl2(SEt2)(2) associated vith tetrabutyl ammonium bromide. Using this catalytic protocol, aryl iodides and bromides. and electron-poor aryl chlorides Lire coupled with n-butylacrylate and styrene under relatively mild reaction conditions with high catalytic activity. Reaction vessel ultra-trace amounts (ppt) of this Pd precursor promotes the ccupling of iodo benzene with n-butylacrylate with turnover numbers (mol product mol Pd) Lip to 10 degrees. (C) 2001 Elsevier Science Lid. All rights reserved.