Journal
TETRAHEDRON LETTERS
Volume 42, Issue 42, Pages 7333-7335Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01525-8
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A new efficient method for the preparation of 3-(4-pyridinyl)methylindoles has been developed. The new method involves coupling of indoles with 4-pyidinecarboxaldehyde to give 3-indolyl 4-pyridinyl methanols, which upon treatment xvith tricthylsilane in the presence of trifluoroacetic acid afford 3-(4-pyridinyl)methylindoles in 64-76% overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.
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