Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 429, Issue 1-3, Pages 139-145Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(01)01315-2
Keywords
antinociception; morphine; neuropathic pain; sympathectomy
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We studied the contribution of peripheral opioid receptors to the morphine-induced. antinociception in rats with a spinal nerve ligation-induced neuropathy, Intraplantar (i.pl.) injection of morphine produced a stronger suppression of nociceptive reflex responses of the neuropathic limb following ipsilateral, than contralateral, administration, whereas the morphine-induced effect on the control limb was independent of the injection side. Antinociception induced by systemically administered morphine was significantly attenuated by i.pl. injection of a peripherally acting opioid receptor antagonist in neuropathic but not in sham-operated rats. Following chemical sympathectomy with 6-hydroxydopamine, antinociception was achieved at a lower dose ipsilaterally, than contralaterally, following i.pl. administration of morphine, and the morphine-induced antinociception was attenuated by a peripherally acting opioid receptor antagonist. These results indicate that peripheral opioid receptors may contribute to the morphine-induced antinociception in the spinal nerve ligation-induced model of neuropathy. Sympathectomy of the neuropathic limb may underlie, at least partly, the increased peripheral efficacy of morphine in neuropathy. (C) 2001 Elsevier Science B.V. All rights reserved.
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