Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 112, Issue 2, Pages 96-102Publisher
WILEY
DOI: 10.1111/j.1742-7843.2012.00934.x
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Funding
- Unit of Scientific Research Project, Suleyman Demirel University [BAP: 2881-YL-11]
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It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood. We investigated the effects of selenium on H2O2-induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques.
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