4.4 Article

Elevated substance p levels in HIV-infected men

Journal

AIDS
Volume 15, Issue 15, Pages 2043-2045

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200110190-00019

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Funding

  1. NIMH NIH HHS [R01 MH49981, R01 MH46618] Funding Source: Medline

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The neuropeptide, substance P, is a potent modulator of neuroimmunoregulation. Substance P and its receptor modulate HIV infection. HIV-seropositive men had significantly higher plasma substance P levels compared with uninfected controls, which were associated with decreased CD16 and CD56 natural killer (NK) cell populations. The changes in plasma substance P levels and decreases in NK subsets did not correlate with CD4 cell levels, but a diurnal pattern was suggested for substance P. The balance between substance P expression and functions of immune cells may be important in the immunopathogenesis of HIV infection.

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