Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 109, Issue 6, Pages 434-437Publisher
WILEY
DOI: 10.1111/j.1742-7843.2011.00745.x
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Funding
- Danish Agency for Science, Technology and Innovation
- ISMF
- Danish Research Council
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Maternal pulmonary exposure to ultrafine particles during pregnancy may affect the health of the child. Developmental toxicity of carbon black (Printex 90) nanoparticles was evaluated in a mouse model. Time-mated mice were intratracheally instilled with Printex 90 dispersed in Millipore water on gestation days (GD) 7, 10, 15 and 18, with total doses of 11, 54 and 268 mu g Printex 90/animal. The female offspring prenatally exposed to 268 mu g Printex 90/animal displayed altered habituation pattern during the Open field test.
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