Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 107, Issue 2, Pages 698-699Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1742-7843.2010.00566.x
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This report involves a 54-year-old man who died following refractory ventricular fibrillation after ingestion of a plant in a suicide attempt. Repeated direct-current cardioversions were unsuccessful and no single anti-arrhythmic agent was effective for arrhythmia control. The routine blood toxicological screening was negative. Aconitine, the main toxin of Aconitum napellus was identified using a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The whole blood concentration (24 mu g/l) was higher than those reported in other aconitine-related deaths. The patient had found information about the life-threatening nature of such a toxic herb intake on a free medical encyclopaedia online.
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