4.5 Article

Gln27→Gluβ2-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol

Journal

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 104, Issue 5, Pages 374-378

Publisher

WILEY-BLACKWELL
DOI: 10.1111/j.1742-7843.2008.00370.x

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Funding

  1. FONDECYT [1010992]
  2. FONDAP [15010006]
  3. DID [14-02/01]

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We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln(27)-> Glu beta(2)-adrenergic receptor polymorphism. Carvedilol significantly increased the left ventricular ejection fraction, while decreasing the heart rate and malondialdehyde plasma concentrations in chronic heart failure patients with the Glu(27)->beta(2)-adrenergic receptor allele. There were however, no significant changes in patients with the Gln(27)->beta(2)-adrenergic receptor variant.

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